ea0014oc4.3 | Neuroendocriology basis | ECE2007
Gomes Leonor
, Prazeres Hugo
, Paiva Isabel
, Ribeiro Cristina
, Rebelo Olinda
, Martins Teresa
, Lacerda Manuela
, Carvalheiro Manuela
Objective: The pathogenesis of pituitary tumours is still incompletely understood. Somatotropinomas occur both sporadically and in the context of familial syndromes, such as multiple endocrine neoplasia type 1 (MEN1), Carney complex (CNC) and isolated familial somatotropinoma (IFS). Recently, germline mutations were reported in AIP (aryl hydrocarbon receptor interacting protein) gene in Finish and Italian families and in Finish patients with apparently sporadic pituitar...